Erectile dysfunction treatment
Erectile dysfunction is common, treatable, and often a window into overall health. This guide explains what ED means, what causes it, and how it is treated, for men and for women.
What ED means
Erectile dysfunction means the persistent inability to get or keep an erection firm enough for satisfying sex. It is one of the most common sexual health concerns in men, and it is treatable in most cases. Just as important, ED can be an early signal of problems elsewhere in the body, especially the heart and blood vessels. Bringing it up with a clinician is not only about sex. It is about health.
What causes it: body versus mind
Causes of ED fall into two broad groups, and they often overlap.
Medical and physical causes
- Heart and blood vessel disease
- Diabetes
- High blood pressure
- Low testosterone
- Nerve problems, including after prostate or pelvic surgery
- Smoking
- Heavy alcohol use
- Obesity
- Poor sleep
Mental health and relationship causes
- Performance anxiety
- Depression
- Chronic stress
- Conflict with a partner
- Past trauma
A man with a heart condition can develop anxiety about performance, and a man whose ED started with stress can develop a physical pattern over time. Good care looks at both sides, not just one.
Why we ask about morning erections
One of the first questions a clinician will ask is whether you still wake up with an erection. There is a good reason for that. During deep sleep, the nervous system runs a kind of automatic test. Blood flows and erections happen on their own, with no desire or stimulation needed. If those morning erections are still happening, the blood vessels and nerves are probably working fine, which points toward a psychological cause such as anxiety or stress. If morning erections have faded away, it points more toward a physical cause. It is a simple question, and it tells us a lot. There is no need to feel embarrassed about it. We ask because it helps us find the right treatment.
Treatment options: men and women side by side
Women do not get erections, but they have their own version of this story: low desire, trouble with arousal, or pain. The medicines below are grouped by what is FDA approved and what is used off label.
For men
FDA approved
- Sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra), avanafil (Stendra). All four are PDE5 inhibitors. They improve blood flow to support an erection during sexual stimulation. They do not create desire, and they do not work without stimulation.
Off label or second line
- Alprostadil, given as a small injection or as a pellet placed in the urethra.
- Vacuum erection devices, which draw blood into the penis with gentle suction.
- Testosterone, only when blood tests show true deficiency. Extra testosterone does not fix ED on its own.
Safety note: PDE5 inhibitors must never be combined with nitrates, the heart medicines such as nitroglycerin used for chest pain. The combination can cause a dangerous drop in blood pressure.
For women
Both FDA approved medicines for women treat low sexual desire in premenopausal women. Neither one is approved for arousal problems.
FDA approved
- Flibanserin (Addyi): a daily pill taken at bedtime that works on brain chemistry related to desire. Benefits are modest. Key risk: combined with alcohol it can cause dangerous drops in blood pressure and fainting, so alcohol must be avoided. Sleepiness and dizziness are also common.
- Bremelanotide (Vyleesi): an injection used on demand before sexual activity. Benefits are modest. Key risks: it can raise blood pressure, and nausea is common.
Off label
- Sildenafil has been studied in women with mixed results. It helped arousal in some studies of postmenopausal women, but it did not improve desire, and it never earned FDA approval for women.
Why Viagra is not interchangeable for women
In men, an erection is largely a blood flow event. Sexual stimulation releases a chemical signal, blood vessels relax, blood flows in, and a PDE5 inhibitor strengthens that signal. In women, low desire and arousal problems are rarely just about blood flow. They involve brain chemistry, hormones, blood flow, pain, mood, and the relationship itself. A drug that only boosts blood flow cannot fix that wider picture, which is why the trials in women were mixed and why no PDE5 inhibitor earned FDA approval for women. Different biology needs different tools.
Start with the foundations
Before any prescription, the foundations matter for both men and women. Regular exercise, steady weight loss when needed, quitting smoking, drinking less alcohol, better sleep, and managing stress all improve sexual function. Counseling or sex therapy helps when performance anxiety, depression, or relationship strain are part of the picture.
It also helps to review your current medicines with your prescriber, because several common drugs can cause or worsen ED:
- SSRIs and SNRIs, the most commonly prescribed antidepressants
- Some antipsychotics
- Thiazide diuretics, water pills used for blood pressure
- Beta blockers
- Finasteride, used for hair loss or prostate enlargement
- Opioids, prescription pain medicines
Never stop a prescribed medicine on your own because of this list. Talk with your prescriber about options, since there is often a way to adjust the plan without losing the benefit of the medicine.
This page is for education only and is not medical advice. Talk with your own clinician before starting, stopping, or changing any medicine.
When to talk to us, and when to see your other doctors
In our practice, we handle the mental health and medication related side: SSRI related sexual side effects, performance anxiety, depression related low libido, and the stress and relationship strain around it. Heart disease, hormone problems, and anatomic causes belong with your primary care clinician or a urologist. The best outcomes come from coordinated care, and we are glad to work alongside your other clinicians.
Research and further reading
A few key papers behind how erectile dysfunction and related treatments are understood today. Links open the abstract on PubMed, a free public database from the U.S. National Library of Medicine.
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Oral sildenafil in the treatment of erectile dysfunction
Goldstein et al. · N Engl J Med · 1998
In two trials totaling 861 men, 69 percent of attempts at intercourse succeeded with sildenafil versus 22 percent with placebo. Headache, flushing, and indigestion were the most common side effects.
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Tsertsvadze et al. · Ann Intern Med · 2009
Across short term trials, PDE5 inhibitors improved erections in 67 to 89 percent of men versus 27 to 35 percent with placebo. Head to head trials found no clear winner among sildenafil, vardenafil, and tadalafil.
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Flibanserin for Premenopausal Hypoactive Sexual Desire Disorder: Pooled Analysis of Clinical Trials
Simon et al. · J Womens Health · 2019
Pooling the VIOLET, DAISY, and BEGONIA trials in 2,465 premenopausal women, flibanserin modestly increased satisfying sexual events and desire scores versus placebo. Dizziness and sleepiness were the most common side effects.
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Katz et al. · J Sex Med · 2013
In 1,087 premenopausal women treated for 24 weeks, nightly flibanserin improved desire and reduced distress versus placebo. About 1 in 10 stopped treatment because of side effects.
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Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials
Kingsberg et al. · Obstet Gynecol · 2019
In two identical trials of 1,267 premenopausal women, on demand bremelanotide improved desire and reduced distress versus placebo. Nausea, flushing, and headache were the most common side effects.
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Berman et al. · J Urol · 2003
In 202 postmenopausal women, sildenafil improved arousal and satisfaction versus placebo, but only in women without low desire. It did not help desire itself.
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